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What is Adderall?
Adderall is a combination medicine containing amphetamine and dextroamphetamine. It is generally well-tolerated and effective in treating the symptoms of ADHD and narcolepsy. At therapeutic doses, Adderall often causes emotional and cognitive effects such as euphoria, change in sex drive, increased wakefulness, and improved cognitive control.
At these doses, Adderall induces physical effects such as fatigue resistance, a faster reaction time, and increased muscle strength. In contrast, significantly larger amounts of Adderall can cause rapid muscle breakdown, impair cognitive control, provoke panic attacks, or induce a psychosis (e.g., hallucinations, paranoia, delusions).
When given for ADHD, Adderall should be used in conjunction with other treatment strategies, such as psychotherapy, social integration advice, and education about the disorder. FDA has approved the use of Adderall in children over the age of three.
At these doses, Adderall induces physical effects such as fatigue resistance, a faster reaction time, and increased muscle strength. In contrast, significantly larger amounts of Adderall can cause rapid muscle breakdown, impair cognitive control, provoke panic attacks, or induce a psychosis (e.g., hallucinations, paranoia, delusions).
When given for ADHD, Adderall should be used in conjunction with other treatment strategies, such as psychotherapy, social integration advice, and education about the disorder. FDA has approved the use of Adderall in children over the age of three.
Clinical trials and medical uses of Adderall
- Adderall is used to treat ADHD (or attention deficit hyperactivity disorder) and narcolepsy (a sleep disorder). Long-term amphetamine exposure at sufficiently large doses in some animal species produces abnormal dopamine system development or nerve damage.
- However, in humans with ADHD, pharmaceutical amphetamines appear to improve brain development and nerve growth at therapeutic dosages.
- Reviews of MRI or magnetic resonance imaging studies suggest that long-term treatment with amphetamine reduces brain function and structure abnormalities found in subjects with ADHD. It improves function in several parts of the brain, like the right caudate nucleus of the basal ganglia.
- Reviews of clinical stimulant research using Adderall have established the effectiveness and safety of long-term continuous amphetamine use for the treatment of ADHD. Two studies have suggested that long-term continuous stimulant therapy with Adderall for ADHD effectively reduces the significant symptoms of ADHD (i.e., inattention, hyperactivity, and impulsivity), enhancing the quality of life and academic achievement.
- It also produces improvements in many functional outcomes across several categories of outcomes. These can be related to academics, antisocial behavior, driving, self-esteem, service use (i.e., academic, occupational, health, financial, and legal services), non-medicinal drug use, obesity, occupation, and social function.